. 2008 May 21;29(7):1380–1385. doi: 10.1093/carcin/bgn121

Table V.

Association between haplotypes in block1 of DNMT1 or DNMT3B and a number of BPDE-induced chromatid breaks per cell

Haplotype	Frequency (%)	Effect per haplotype allele		P-value^b	Permuted P-value^b ^c	Likelihood ratio P-value^d
Haplotype	Frequency (%)	Estimate^a	95% CI	P-value^b	Permuted P-value^b ^c	Likelihood ratio P-value^d
DNMT1					0.015	0.037
H284	51	1.16	1.05–1.28	0.003
H200	36	0.87	0.79–0.97	0.010
H48	9	1.03	0.86–1.23	0.760
Hother	4	0.87	0.70–1.08	0.203
DNMT3B					0.056	0.023
H145	22	0.94	0.82–1.07	0.321
H149	20	1.02	0.89–1.16	0.785
H91	14	0.99	0.84–1.16	0.893
H70	11	1.24	1.05–1.45	0.009
H49	8	0.93	0.77–1.12	0.445
Hother	25	0.93	0.82–1.04	0.205

CI, confidence interval.

Estimate is the ratio of breaks per cell between any common haplotype and all other haplotypes in each gene.

P-value is from multiple linear regression model comparing haplotype to all other haplotypes and including adjustment for sex, seeding count and current smoking status.

The mutagen sensitivity data were permuted for the 278 subjects 10 000 times at random. Permuted P-values were calculated based on Chen et al. (28).

P-value is from multiple linear regression model with all haplotypes considered simultaneously and adjustment for sex, seeding count and current smoking status.