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siRNA knockdown of μ-calpain in FA-A cells leads to increased cell viability after damage with MMC. FA-A cells were transfected with 200, 240 or 300 pM μ-calpain siRNA or nontarget (Nt) siRNA. Normal cells were transfected with Nt siRNA or 300 pM μ-calpain siRNA. Cells were treated with MMC (400 nM) 24 hr after transfection and cell viability was examined 0 hr, 16 hr, 24 hr, and 48 hr after MMC treatment. Vertical lines represent ± s.e.m. for 5–8 experiments.
