. Author manuscript; available in PMC: 2011 Jul 1.

Published in final edited form as: Clin Cancer Res. 2010 Jun 30;16(13):3463–3472. doi: 10.1158/1078-0432.CCR-09-3304

Table 5. Methylation sensitivity and specificity for multiple markers.

ROC curves were established for multiple markers. All four markers used in combination had the greatest sensitivity and specificity.

Gene	Frequency of positivity		P	AUC	Sensitivity %	Specificity %
Gene	Controls	Cancers	P	AUC	Sensitivity %	Specificity %
KIF1A, DCC, RARb, NISCH	23 of 80	51 of 70	0.0001	0.643	73	71
DCC, RARb, NISCH	22 of 80	47 of 70	0.0001	0.569	67	73
Kif1A, NISCH, RARb	24 of 80	43 of 70	0.0001	0.639	62	70
KIf1A, DCC, NISCH	22 of 80	46 of 70	0.0001	0.573	68	73
KIF1A, DCC, RARb	6 of 80	30 of 70	0.0001	0.597	43	93
DCC, NISCH	20 of 80	40 of 70	0.0001	0.607	57	75
KIF1a, NISCH	21 of 80	38 of 70	0.0004	0.608	54	74
RARB, NISCH	23 of 80	37 of 70	0.0027	0.599	28	71
KIF1A, DCC	7 of 80	26 of 70	0.0001	0.619	37	91
DCC, RARB	6 of 80	24 of 70	0.0001	0.586	34	93
KIF1a, RARB	4 of 80	19 of 70	0.0002	0.761	27	95