Table I.
Efficacy of pterostilbene in the AOM-induced colon cancer model in F344 male rats: tumor incidence and tumor multiplicity
| Experimental groupa | No. of animals at autopsy | Body weight at autopsy (mean ± SE) (g) | Tumor incidenceb (rats with colon tumors/total no. of rats) | Tumor multiplicityc (no. of NIA per rat) (mean ± SE) | Tumor multiplicityc (no. of invasive AC per rat) (mean ± SE) | Serum level of pterostilbened (mean ± SE) (ng/ml) | Colon mucosa level of pterostilbened (mean ± SE) (ng/g) |
| Control diet | 24 | 439 ± 6.6 | 21/24 (87.5%) | 1.79 ± 0.28 | 0.21 ± 0.08 | N.D.e | N.D.e |
| Pterostilbene | 28 | 445 ± 5.5 | 19/28 (67.8%) | 1.07 ± 0.21(P = 0.04) | 0.07 ± 0.05 | 48.0 ± 6.9 | 10.9 ± 3.8 |
a
Pterostilbene (40 p.p.m.) was administered in the diet starting at one day after the second AOM treatment and continuously thereafter for 45 weeks.
b
Tumor incidence was analyzed by two-tailed Fisher’s exact probability test. No statistical significance was observed.
c
Tumor multiplicity was analyzed by the Student’s t-test.
d
Samples were randomly selected from the control (serum, n = 10; colon mucosa, n = 10) or pterostilbene-fed groups (serum, n = 8; colon mucosa, n = 6) for analysis.
e
N.D.: Not detectable.