Table 5.
Group | Pre-arrest | Post-resuscitation phase | Friedmann | ||||
5 min | 30 min | 90 min | 240 min | ||||
pH hep ven | TELM | 7.42 ± 0.01 | 7.21 ± 0.02* | 7.29 ± 0.02 | 7.40 ± 0.01 | 7.44 ± 0.01 | P < 0.0001 |
Control | 7.42 ± 0.01 | 7.24 ± 0.01* | 7.31 ± 0.01 | 7.39 ± 0.01 | 7.43 ± 0.01 | P < 0.001 | |
PHVO2 | TELM | 37.9 ± 1.6 | 29.4 ± 3.2 | 36.3 ± 1.8 | 34.4 ± 3.8 | 33.4 ± 1.7 | ns |
(mmHg) | Control | 34.7 ± 2.8 | 28.2 ± 3.3 | 31.7 ± 2.3 | 31.2 ± 2.0 | 29.1 ± 2.9 | ns |
PHVCO2 | TELM | 45.1 ± 1.1 | 57.7 ± 1.7* | 52.1 ± 2.4 | 45.7 ± 1.1 | 45.9 ± 0.8 | P < 0.0001 |
(mmHg) | Control | 46.3 ± 1.5 | 58.9 ± 1.6* | 54.0 ± 1.6 | 47.2 ± 0.8 | 45.8 ± 0.9 | P < 0.001 |
BE | TELM | 4.5 ± 0.5 | -5.3 ± 1.0* | -1.8 ± 1.1 | 2.9 ± 1.3 | 6.1 ± 0.6 | P < 0.0001 |
Control | 4.9 ± 0.4 | -3.1 ± 0.4* | +0.1 ± 0.9 | 4.0 ± 1.4 | 5.7 ± 1.0 | P < 0.001 |
pH hep ven = hepatic venous pH; PHVO2 = hepatic venous partial pressure of oxygen; PHVCO2 = hepatic venous partial pressure of carbon dioxide; BE = base excess; TELM = angiotensin II antagonist telmisartan; ns = not significant. *P < 0.05 vs pre-arrest values by Wilcoxon matched pairs test.