. Author manuscript; available in PMC: 2010 Jul 8.

Published in final edited form as: Pharm Res. 2009 Sep 11;26(11):2513–2522. doi: 10.1007/s11095-009-9967-2

Table I.

Influence of Puncture Protocol on the Cumulative Number of Microorganisms Crossing Silescol® Membranes after 24 h and the Numbers of Microorganisms Adherent to Hypodermic needles or Microneedle Arrays on Removal. For Both Sets of Data, Numbers are Compared with the Total Microbial Load on Unpunctured Control Membranes

		Cumulative number of microorganisms crossing Silescol® membrane after 24 h (cfu)	Number of microorganisms adherent to hypodermic needle or MN array on removal (cfu)

		(% of original count on control membranes)	(% of original count on control membranes)

Treatment	Microorganism	(means ± S.D., n=3)	(means ± S.D., n=3)
Hypodermic Needle	C. albicans	4.3±0.2×10⁵ (40.2%)	2.4±0.9×10³ (0.23%)
	P. aeruginosa	9.8±0.6×10⁴ (4.5%)	4.7±0.6×10³ (0.21%)
	S. epidermidis	3.1±0.2×10⁴ (0.5%)	2.4±1.0×10³ (0.03%)
MN Punctured & Left	C. albicans	2.1±0.4×10³ (0.2%)	5.6±1.1×10⁴ (5.23%)
	P. aeruginosa	2.0±0.2×10³ (0.1%)	5.3±1.0×10⁴ (2.38%)
	S. epidermidis	0.9±0.2×10³ (0.01%)	7.7±1.2×10⁴ (1.04%)
MN Punctured & Removed	C. albicans	4.8±0.3×10⁴ (4.5%)	4.6±0.6×10⁴ (4.30%)
	P. aeruginosa	2.5±0.3×10³ (0.1%)	2.9±1.0×10⁴ (1.30%)
	S. epidermidis	2.1±0.4×10³ (0.03%)	2.7±1.1×10⁴ (0.36%)