Table 2.
Means and Cumulative Declines in 3MS scores over 7 years of Observation*
| Model 1 | Baseline (n=2,957) | 3 years (n=2,957) | 7 years (n=1,936) |
|---|---|---|---|
| FhxAD (−), APOE(−) | (reference) | −0.32 (−0.62 to −0.03) | −2.91 (−3.37 to −2.44) |
| FhxAD (+), APOE(−) | 0.02 (−0.49 to 0.53) | −0.25 (−0.81 to 0.31) | −2.69 (−3.55 to −1.83) |
| FhxAD (−), APOE(+) | −0.70 (−1.15 to −0.24)a | −2.21 (−2.69 to −1.72) | −6.64 (−7.38 to −5.90)b |
| FhxAD (+), APOE(+) | −0.46 (−1.09 to 0.16) | −2.37 (−3.09 to −1.66) | −9.75 (−10.82 to −8.67)b |
| Model 2 | Baseline (n=2,145) | 3 years (n=2,145) | 7 years (n=1,369) |
| FhxAD (−), APOE(−) | (reference) | 0.37 (0.09 to 0.66) | −1.03 (−1.43 to −0.63) |
| FhxAD (+), APOE(−) | −0.26 (−0.80 to 0.28) | 0.19 (−0.36 to 0.74) | −1.30 (−2.06 to −0.55) |
| FhxAD (−), APOE(+) | −0.42 (−0.91 to 0.07) | 0.44 (−0.05 to 0.92) | −0.82 (−1.46 to −0.19) |
| FhxAD (+), APOE(+) | −0.58 (−1.30 to 0.13) | 1.37 (0.60 to 2.15) | −1.54 (−2.59 to −0.50)c |
*
Models are adjusted for baseline age, sex, education, time, time2, and interactions between each group with time and time2.
Model 1 includes all study participants.
Model 2 excludes individuals diagnosed with prodromal AD or dementia.
a
p-value=0.003 compared with reference group
b
p-value<0.0001 compared with reference group
c
p-value=0.007 compared with reference group