Figure 6. Induction heat maps of Notch1 target genes involved in mesoderm development, intracellular signalling cascade, cell proliferation and cytoskeleton.

The identified Notch1 targets were grouped into different Gene Ontology (GO) terms using the DAVID functional annotation analysis tool (http://david.abcc.ncifcrf.gov/). Note that only differentially regulated genes by Notch1 are shown as Log₂ transformed values. If no gene symbol was available for the regulated transcript, GenBank accession number was given in parentheses. Significant changes of differentially regulated gene expression according to the criteria outlined in Material and Methods were labeled with a black or white dot for up- and down-regulated genes, respectively. Redundant probe sets for the same gene were removed except when significantly different results were obtained (e.g. Sox9). The complete list of regulated genes is available in the Supplement Table S1.