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. 2010 Jul 8;5(7):e11481. doi: 10.1371/journal.pone.0011481

Figure 11. Expression of Notch1 target genes is altered in RBP-J deficient ES cells.

Figure 11

mRNA levels were measured by qPCR in ES cells cultured in self renewal medium (ESCs). The error bars indicate the standard deviation from 3 independent experiments. (A) Expression of potentially direct Notch1 target genes is increased in RBP-J deficient ES cells. Fold expression in relation to the expression of RBP-J +/+ D3 cells is shown. (B) The increased expression of Notch1 target genes in RBP-J -/- ES cells is repressed by exogenous RBP-J expression and further increased by a transcriptionally active form of RBP-J (RBP-J-VP16). Fold expression in relation to the expression of cells transfected with the control vector is shown.