Figure 1.

Genes identified by transcriptome analysis in monocytes of HIV patients versus healthy controls. A) Genes passing RT-qPCR and training/comparison set validation; mean fold change between the comparison set and healthy controls as assessed by RT-qPCR is shown at baseline and at 3, 6 and 9 months of therapy.¹: the Official Gene Symbol (OGS, Entrez Gene); ²: the Entrez Gene identification code;³: Classification system (evidence for these classifications was derived from the Gene Ontology annotations, except where indicated); B) Genes identified only in patients with CD4T ≤ 400 cells/mm³ and/or VL ≥ 5 log copies/ml; mean fold change between the comparison set and healthy controls as assessed by RT-qPCR is shown at baseline and at 3, 6 and 9 months of therapy. C) Genes identified by ANOVA as differentially regulated during therapy; mean fold change between the comparison set and healthy controls as assessed by RT-qPCR is shown at baseline and at 3, 6 and 9 months of therapy.