Figure 2. Gene map and LD plot of TERT-CLPTM1L locus and associated SNPs.

Colour scheme is based on r² values in Haploview; white r² = 0; shades of grey 0<r²<1; black r² = 1. Block definition is based on the method of Gabriel et al [54]. (A) Gene map of SNPs genotyped in the discovery stage (underlined) relative to other TERT SNPs associated with cancer phenotypes (inset) and LD plot based on HapMap CEU samples. (B) Haploview plot of all TERT SNPs genotyped in 1,047 non-Hispanic White controls in our study; numbers in squares are pairwise r² values between SNPs.