Table 4. Combined discovery and replication analysis: risk estimates for TERT rs7726159 for all races according to tumor behaviour and histological subtypes.

				Heterozygotes			Homozygotes			Per-Allele
Tumor Behavior	Histological Subtype	aControls	aCases	bOR	(95% CI)	P	bOR	(95% CI)	P	bOR	(95% CI)	P
Invasive	Serous	4138	2196	1.30	(1.16–1.45)	5.7×10−6	1.25	(1.05–1.49)	0.011	1.17	(1.08–1.27)	7.21×10−5
	Mucinous	4138	271	1.15	(0.88–1.49)	0.31	1.01	(0.66–1.54)	0.98	1.05	(0.87–1.26)	0.63
	Endometrioid	4138	454	0.81	(0.65–0.99)	0.045	1.09	(0.80–1.48)	0.57	0.96	(0.83–1.12)	0.64
	Clear Cell	4138	261	1.03	(0.79–1.35)	0.83	1.12	(0.75–1.69)	0.57	1.05	(0.87–1.27)	0.60
	All others	4138	355	1.08	(0.86–1.37)	0.50	1.49	(0.80–1.64)	0.45	1.07	(0.91–1.26)	0.38
Borderline/LMP	Serous	4138	251	1.63	(1.21–2.18)	0.001	2.04	(1.38–3.02)	0.0004	1.46	(1.21–1.76)	6.63×10−5
	Mucinous	4138	249	1.13	(0.85–1.49)	0.40	0.85	(0.53–1.36)	0.51	0.99	(0.81–1.21)	0.92

^aCases and controls derived from AUS, MAL, MAY, SEA, UKO and USC studies.

^bEstimates are adjusted for age (at interview in controls, at diagnosis in cases), race and study site.