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. Author manuscript; available in PMC: 2010 Jul 8.
Published in final edited form as: Cell. 2007 Dec 14;131(6):1179–1189. doi: 10.1016/j.cell.2007.10.055

Figure 1. A QTL with a major effect on gill pigmentation.

Figure 1

(A) Segregating variation in melanocyte distribution within the gills of Japanese marine × Paxton benthic F2 fish. F2 fish show a range of gill pigmentation, from gills with few melanocytes and overall white appearance (class “1”), to intermediate (classes “2” and “3”), to gills with many melanocytes and overall dark brownish appearance (class “4”).

(B) Mapping results on linkage group 19. Genetic distance in centiMorgans (cM) is on the x-axis, and LOD score on the y-axis. Significance threshold is 4.5 (van Ooijen, 1999). Markers from left to right are Stn303, Stn185, Stn186, Stn187, Stn193, Stn194, Stn191, Stn398, Stn399, Stn400.

(C) Gill pigmentation phenotypes of F2 fish according to genotype at Stn191, the peak QTL marker (mean scores +/− SEM). Since the grandparents were a Japanese marine female and Paxton benthic male, F2 fish can have any of four LG19 genotypes. Females can either be homozygous for marine chromosomes (XMXM) or heterozygous for marine and Paxton benthic chromosomes (XMXB). Males all have the benthic Y chromosome (YB), and can have a marine or freshwater X chromosome. Differences between genotypic classes are highly significant for both males (p = 9 × 10−40) and females (p = 2 × 10−8).