Table 1.
Characteristics of the studies* included in the systematic review of the use of the Thrombolysis in Myocardial Infarction (TIMI) risk score to predict the short-term risk of acute myocardial infarction, coronary revascularization or death
| Study | Location | No. (%) of men | Mean age (SD) | Definition of myocardial infarction used | Duration and method of follow-up | No. (%)lost to follow-up | No. (%) of patients with cardiac events |
|---|---|---|---|---|---|---|---|
| Body et al20 | Manchester, UK | 796 (60.4) | 58.9 (14.2) | ESC/ACC criteria | 30-day; MRR, phone follow-up | 0 (0.0) | 123 (15.3) |
| Campbell et al18 | Pennsylvania, USA | 3169 (45.0) | 53.6 (14.5) | ESC/ACC criteria | 30-day; MRR, phone follow-up | 141 (4.4) | 229 (7.2) |
| Conti et al14 | Florence, Italy | 210 (61.4) | 71.3 (11.2) | Not available | 6-month‡; MRR, phone follow-up | Not available | 35 (16.6) |
| García Almagro et al15 | Murcia, Spain | 1254 (57.4) | 54.0 (19.0) | Not available | 6-month‡; follow-up methods not available | 64 (5.1) | 46 (3.7) |
| Hess et al16 | Ottawa, Canada | 1017 (60.6) | 59.3 (13.8) | Elevated troponin T | 30-day; MRR, phone follow-up | 47 (4.6) | 117 (11.5) |
| Lyon et al22 | Scotland, UK | 954 (62.0) | 60.0 (range 20–85) | Elevated troponin | 30-day; MRR, phone follow-up | 26 (3.4) | 137 (18.0) |
| Pelliccia et al17 | Rome, Italy | 4333 (68.8) | 58.4 (23.1) | Elevated CK- MB or troponin I | Hospital discharge; MRR, in- hospital assessment | 0 (0.0) | 1106 (25.5) |
| Pollack et al19 | Philadelphia, USA | 3929 (40.0) | 51.6 (15.6) | ESC/ACC criteria | 30-day; MRR, phone follow-up | 79 (2.0) | 335 (8.5) |
| Sanchis et al21 | Valencia & Barcelona, Spain | 646 (65.8) | 64.0 (12.0) | Elevated troponin I or CK-MB | 14-day†; follow-up methods not available | 11 (1.7) | 42 (6.5) |
| Tong et al23 | Virginia, USA | 957 (52.0) | 60.0 (range 32–92) | Elevated troponin I | 30-day; MRR, phone follow-up | 86 (7.0) | 98 (9.3) |
Note: CK-MB = creatine kinase–muscle and brain; MRR = medial record review; ESC/ACC = European Society of Cardiology/American College of Cardiology; STEMI = ST-segment elevation myocardial infarction; ACS =Acute coronary syndrome.
All studies enrolled patients presenting to the emergency department with chest pain.
For purposes of comparison, we ascertained 30-day outcomes by contacting the primary author.
Data regarding the number of patients and the number with cardiac events in each stratum of the TIMI risk score not available.