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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Nat Immunol. 2010 Jun 6;11(7):628–634. doi: 10.1038/ni.1888

Figure 4.

Figure 4

Activation of Rag2+/+ 8.8 T cells by wild-type vaccinia virus requires expression of endogenous TCR chains. (a) Splenocytes (2.5 × 106) from wild-type mice were transferred into Rag2+/+ and Rag2−/− 8.8 mice (five mice/group) and the mice were infected with wild-type vaccinia virus two weeks later. There is a significant difference in weight loss (P <0.0001) between infected Rag2+/+ compared to Rag−/− 8.8 mice. Error bars represent s.e.m. (b) The ability of infected Rag2+/+ and Rag2−/− 8.8 mice to specifically lyse MBP peptide-pulsed splenocytes in vivo was assessed as described Fig. 1c. Data are representative of four experiments.