Table 1.

Region pairs for which there is significant difference in anatomical connectivity. Anatomical connectivity is lower in patients and negatively correlated with positive PANSS subscores for all region pairs. The anatomical position of those connections is presented on figure 1.

ROI 1	ROI 2	Functional Correlation Group Difference (t-value)	Functional Connectiv ity PANSS correlation (r-value)	Function al Connecti vity TDI correlatio n (r- value)	Anatomic al Connectiv ity Group Difference t-value	Anatomical Connectivity PANSS correlation (r- value)	Anatomic al Connecti vity TDI correlatio n (r- value)
Angular Left	Cingulate	−0.9	−0.39	−0.10	*−2.9	*−0.50	−0.22
inferior parietal lobule Left	Cingulate	0.8	−0.09	−0.09	*−3.5	*−0.52	−0.24
Insula Right	Lingual	−2.0	−0.39	−0.18	*−3.3	*−0.49	−0.08
Insula Right	Middle Temporal Gyrus Right	0.12	−0.17	−0.29	*−3.5	*−0.51	−0.11
Lingual	Middle Temporal Gyrus Right	2.1	−0.08	0.03	−*3.2	*−0.50	−0.14
Inferior Frontal Gyrus Left	Postcentral Left	0.6	−0.35	0.21	**−4.0	*−0.48	−0.18
Insula Left	Postcentral Left	0.7	0.01	0.18	**−4.0	*−0.48	−0.18
Middle Temporal Gyrus Left	Postcentral Left	*−2.9	*−0.48	−0.03	**−3.8	**−0.51	−0.17
Postcentral L	Superior Temporal Gyrus Left	−0.3	0.00	0.17	**−3.9	*−0.49	−0.18
Insula Right	Superior Temporal Gyrus Right	−0.7	0.02	−0.19	*−3.4	*−0.49	−0.02
Lingual	Superior Temporal Gyrus Right	−1.5	0.15	−0.09	*−3.2	*−0.55	−0.06
Middle Temporal Gyrus Right	Superior Temporal Gyrus Right	1.3	−0.48	−0.35	*−3.4	*−0.49	−0.10

^*denotes p<0.02,

^**p<0.01.