Table 1.
Means and standard errors (S.E.) of cytochrome oxidase activity (micromole/min/gram wet tissue) of regions of interest in fluoxetine-treated (n=7) and vehicle (n=10) groups.
| Brain Region | Fluoxetine Group Mean ± S.E. |
Vehicle Group Mean ± S.E. |
p value |
|---|---|---|---|
| Habenula and Midbrain Regions | |||
| Habenula | 283.0 ± 6.4 | 305.0 ± 6.1 | .028* |
| Dorsal raphe nuc. | 221.8 ± 6.4 | 207.7 ± 6.8 | .163 |
| Periaqueductal gray | 256.4 ± 10.5 | 235.9 ± 7.1 | .116 |
| Midbrain reticular formation | 190.8 ± 5.2 | 178.7 ± 9.1 | .269 |
| Ventral tegmental area | 177.4 ± 4.5 | 148.2 ± 5.7 | .001* |
| Interpeduncular nuc. | 390.0 ± 8.2 | 381.5 ± 8.7 | .507 |
| Red nuc. | 242.7 ± 14.2 | 250.7 ± 9.8 | .638 |
| Substantia nigra, pars ret. | 236.2 ± 11.8 | 238.7 ± 7.0 | .851 |
| Substantia nigra, pars comp. | 183.9 ± 13.7 | 189.4 ± 7.4 | .711 |
| Superior colliculus, sup. | 251.9 ± 11.7 | 252.2 ± 5.5 | .984 |
| Superior colliculus, deep | 232.3 ± 13.1 | 232.4 ± 5.5 | .998 |
| Inferior colliculus | 349.5 ± 10.1 | 345.1 ± 6.9 | .712 |
| Oculomotor nuc. | 364.5 ± 8.2 | 351.0 ± 5.0 | .156 |
| Hippocampal Regions | |||
| Ant. hipp. CA1, oriens | 188.2 ± 9.6 | 183.3 ± 5.6 | .642 |
| Ant. hipp. CA1, pyr. | 184.1 ± 9.2 | 182.5 ± 5.3 | .871 |
| Ant. hipp., lac.-mol. | 274.9 ± 8.6 | 270.9 ± 3.7 | .646 |
| Ant. hipp., CA3, oriens | 206.5 ± 4.9 | 211.7 ± 5.8 | .531 |
| Ant. hipp., CA3, pyr. | 171.0 ± 4.3 | 174.8 ± 4.2 | .546 |
| Dentate gyrus | 292.5 ± 2.7 | 301.5 ± 3.0 | .046* |
| Post. hipp., CA1 | 208.4 ± 9.9 | 222.0 ± 3.3 | .234 |
| Post. hipp., CA2 | 222.3 ± 9.0 | 232.3 ± 3.0 | .321 |
| Post. hipp., CA3 | 236.6 ± 10.5 | 251.2 ± 4.9 | .242 |
| Subiculum | 252.5 ± 10.6 | 249.8 ± 7.9 | .835 |
| Frontal Cortical Regions | |||
| Infralimbic cortex, sup. | 228.8 ± 5.2 | 239.0 ± 7.2 | .305 |
| Infralimbic cortex, deep | 235.4 ± 5.6 | 245.9 ± 7.1 | .297 |
| Prelimbic cortex, sup. | 261.5 ± 8.6 | 265.2 ± 10.2 | .799 |
| Prelimbic cortex, deep | 257.3 ± 8.4 | 269.5 ± 7.9 | .316 |
| Dorsomedial frontal cortex, sup. | 289.2 ± 7.3 | 287.7 ± 5.8 | .874 |
| Dorsomedial frontal cortex, deep | 209.3 ± 3.8 | 232.3 ± 8.7 | .032* |
| Dorsal frontal cortex, sup. | 293.1 ± 5.9 | 296.7 ± 4.1 | .612 |
| Dorsal frontal cortex, deep | 158.7 ± 8.0 | 178.6 ± 15.5 | .330 |
| Lateral frontal cortex, sup. | 277.9 ± 3.6 | 287.8 ± 4.2 | .115 |
| Lateral frontal cortex, deep | 234.4 ± 7.9 | 241.7 ± 8.1 | .539 |
| Anterior cingulate cortex, sup. | 286.8 ± 17.6 | 293.8 ± 8.7 | .698 |
| Anterior cingulate cortex, deep | 264.2 ± 14.1 | 279.4 ± 7.2 | .310 |
| Thalamic Regions | |||
| Nuc. reuniens | 223.7 ± 10.0 | 228.0 ± 2.7 | .690 |
| Parafascicular nuc. | 228.1 ± 6.3 | 231.3 ± 5.5 | .709 |
| Ventral basal nuc. | 249.0 ± 6.2 | 252.3 ± 3.3 | .617 |
| Subthalamic nuc. | 334.9 ±4.0 | 330.9 ± 6.2 | .637 |
| Ant. dorsal thal. nuc. | 332.0 ± 9.7 | 342.2 ± 4.4 | .303 |
| Ant. ventral thal. nuc. | 259.4 ± 6.9 | 265.8 ± 3.7 | .391 |
| Ant. medial thal. nuc. | 238.7 ± 6.8 | 243.3 ± 4.7 | .574 |
| Lateral geniculate nuc. | 233.8 ± 6.6 | 244.0 ± 4.1 | .182 |
| Medial geniculate nuc. | 266.4 ± 6.7 | 265.7 ± 5.6 | .929 |
| Septal Regions | |||
| Lateral septal nuc. | 295.8 ± 15.4 | 309.6 ± 8.6 | .411 |
| Medial septal diagonal band | 218.6 ± 15.3 | 221.6 ± 8.4 | .856 |
| Basal Ganglia Regions | |||
| Caudate putamen | 320.0 ± 12.7 | 334.8 ± 6.8 | .287 |
| Nucleus accumbens | 259.5 ± 12.1 | 273.0 ± 8.2 | .352 |
| Ventral pallidum | 200.3 ± 10.5 | 201.2 ± 3.4 | .936 |
| Globus pallidus | 161.6 ± 9.7 | 155.8 ± 3.8 | .593 |
| Amygdaloid Regions | |||
| Bed nuc. stria terminalis | 232.0 ± 12.9 | 230.3 ± 3.0 | .908 |
| Basolateral amygdala | 246.8 ± 8.5 | 249.8 ± 6.4 | .778 |
| Central amygdala | 231.7 ± 12.8 | 230.6 ± 8.4 | .942 |
| Medial amygdala | 220.9 ± 13.7 | 219.3 ± 7.6 | .914 |
| Hypothalamic Regions | |||
| Paraventricular hypothal. | 160.2 ± 10.2 | 172.8 ± 4.9 | .229 |
| Lateral hypothal. | 201.3 ± 6.7 | 189.6 ± 4.3 | .142 |
| Suprachiasmatic nuc. | 241.2 ± 14.7 | 219.7 ± 5.5 | .140 |
| Lateral mammillary nuc. | 300.5 ± 7.1 | 311.3 ± 7.9 | .348 |
| Medial mammillary nuc. | 315.8 ± 4.8 | 324.4 ± 7.7 | .360 |
*
p > 0.05.