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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Appl Toxicol. 2010 Jul;30(5):469–475. doi: 10.1002/jat.1518

Figure 4.

Figure 4

Diazinon makes an unusual adduct with BChE. A) MS spectrum shows adducts with masses of 3036.2 and 3064.3 in fraction 37 from the HPLC. These adducts are from the reaction of an isomer of diazinon with BChE. B) MS spectrum shows an adduct with a mass of 3080.5 in fraction 35. The peak at 3080.5 is modified on Serine 198 by diethoxythiophosphate. Alternatively, the 3080.5 mass could come from reaction with a rearranged diazinon to yield thioethyl ethoxyphosphate. C) The MSMS spectrum of the singly charged parent ion m/z 3080.5 demonstrates that the 3080.5 amu peptide is the active site BChE peptide modified on Serine 198 by OP.