Table 1. Participant Characteristics.
| Variables | Overall | apoE4 present (3/4, 4/4) | apoE4 absent (2/2, 2/3, 3/3) |
|---|---|---|---|
| N | 1995 | 426 | 1569 |
| Framingham 10-y stroke risk, % | 6.4 ± 7.3 | 6.2 ± 7.5 | 6.5 ± 7.2 |
| Stroke Risk Profile Components | |||
| Age [mean ± sd] | 61 ± 9 | 61 ± 9 | 61 ± 9 |
| Male (%) | 47% | 46% | 47% |
| Mean Systolic Blood Pressure | 126 ± 18 | 125 ± 19 | 126 ± 18 |
| Diabetes Mellitus (%) | 11% | 12% | 11% |
| Stage 1+ Hypertension (%) | 41% | 43% | 41% |
| History of AF (%) | 3.4% | 2.8% | 3.5% |
| History of CVD (%) | 9% | 11% | 9% |
| Current Smoking (%) | 12% | 9% | 13% |
| Neuroanatomical Measures †† | |||
| Total brain volume [mean ± sd] | 79 ± 3 | 79 ± 4 | 79 ± 3 |
| White matter hyperintensities [med (range)] | 0.05 (0-4.77) | 0.05 (0-1.84) | 0.05 (0-4.77) |
| Frontal Lobe volume [mean ± sd] | 36 ± 3 | 37 ± 3 | 36 ± 3 |
| Temporal Lobe volume [mean ± sd] | 11 ± 1 | 10 ± 1 | 11 ± 1 |
| Temporal horn volume [med (range)] | 0.04 (0-0.55) | 0.04 (0-0.55) | 0.04 (0-0.38) |
| Lateral ventricular volume [mean ± sd] | 1.8 ± 1.2 | 1.8 ± 1.1 | 1.8 ± 1.2 |
| Hippocampal volume [mean ± sd] | 0.32 ± 0.05 | 0.32 ± 0.05 | 0.32 ± 0.04 |
| Neuropsychological Measures | |||
| Logical memory- delayed recall (D. R.) [mean ± sd] | 10.5 ± 3.6 | 10.3 ± 4.0 | 10.6 ± 3.6 |
| Paired associates- D. R.[mean ± sd] | 8.3 ± 1.5 | 8.3 ± 1.6 | 8.3 ± 1.5 |
| Visual Reproduction-D.R. [mean ± sd] | 8.2 ± 3.4 | 8.2 ± 3.4 | 8.2 ± 3.4 |
| Trails A [med (range)] (minutes) | 0.5 (0.2-5.0) | 0.5 (0.2-5.0) | 0.5 (0.2-2.4) |
| Trails B - Trails A [med (range)] (minutes) | 0.7 (-1.5-4.6) | 0.7 (-1.5-4.5) | 0.7 (-0.4-4.6) |
| Similarities [mean ± sd] | 16.8 ± 3.6 | 17.1 ± 3.6 | 16.7 ± 3.6 |
| Hooper Visual Organization Test [med (range)] | 26 (3-30) | 26 (3-30) | 26 (6-30) |
††
neuroanatomical measures were analyzed as a percentage of total cranial volume; the units listed are percentages. For white matter hyperintensities and temporal horn volume, variables were log transformed.