Table 2.
Lack of effect of MPTP treatment on ppN/OFQ mRNA-expressing neurons in the VTA, nucleus of Darkschewitsch (DK) and in dentate gyrus (DG) of hippocampus.
| ppN/OFQ+ cells/mm2 | |||
|---|---|---|---|
| Treatment | VTA | DK | DG |
| Controls (6) | 7.0 ± 1.7 | 220 ± 50 | 34.8 ± 3.1 |
| MPTP, 7 days (8) | 6.9 ± 2.6 | 150 ± 34 | 28.9 ± 4.00 |
| P value | P = 0.949 | P = 0.253 | P = 0.294 |
The table reports the numbers of ppN/OFQ mRNA-expressing neuronal cells or cell clusters/mm2 in three brain regions, the VTA, the DK, and the DG of hippocampus (see Methods for details). MPTP treatment 7 days previously did not significantly alter the numbers of cells expressing ppN/OFQ mRNA in any of these brain regions (analysis by t-test). The numbers in parentheses after each treatment indicate the numbers of animals receiving this treatment.