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. Author manuscript; available in PMC: 2011 Aug 11.
Published in final edited form as: Neuroscience. 2010 May 6;169(1):344–356. doi: 10.1016/j.neuroscience.2010.04.078

Figure 6.

Figure 6

Spine density and length in APP-deficient mice. A, Representative micrograph of a hippocampal CA1 neuron illustrating dendritic regions analyzed. B, Representative dendritic segments of CA1 pyramidal neurons from 12-month-old wild-type (WT), heterozygote (HT), and APP knock-out (KO) animals (N=6 mice/genotype). Scale bar, 5 µm. C, Mean spine density from WT and APP KO mice in CA1 regions (28 neurons/genotype, *p<0.05; **p<0.01). D. Cumulative distribution plot of hippocampal spine length from WT and APP-deficient mice (230–250 spines/genotype, Kolmogorov-Smirnov Test, p<0.001). E. Representative dendritic segments of cortical layer II/III pyramidal neurons from 12-month-old wild-type (WT), heterozygote (HT), and APP knock-out (KO) animals (N=6 mice/genotype). Scale bar, 5 µm. CTX, cortex F. Mean spine density from WT, HT, and KO mice (28 neurons/genotype, *p<0.05; **p<0.01, ***p<0.001). G. Cumulative distribution plot of cortical layer II/III pyramidal neurons spine length from WT and APP-deficient mice (230–250 spines/genotype, Kolmogorov-Smirnov Test, p<0.001).