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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Mol Cell Neurosci. 2010 May 12;44(4):362–373. doi: 10.1016/j.mcn.2010.05.001

Figure 7. GFAP-expressing ancestors give rise to granule neuron precursors that migrate from the EGL to the IGL.

Figure 7

Single 1 µm-thick Z-plane projections of staining for reporter gene expression and cell specific markers in GCE;R26R mice (A–C and J–L) and CGE;CAG-EGFP mice (D–I) analyzed at P12 or P18 after two tamoxifen injections at P5, as indicated. (A–F) Tag1+ and Pax6+ GCPs co-expressing reporter immunoreactivity emerge in the inner aspect of the EGL one week after tamoxifen injection (arrows) and migrate to the IGL. (G–L) EGFP/Zic1/2 and βgal/Dcx double-positive young neurons appear in the inner aspect of the EGL and in the IGL (arrows) 7 and 13 days after tamoxifen treatment, respectively. All images are Apotome acquired 1 µm-thick Z-stack projections. Scale bar, 20 µm.