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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2010 May 5;49(3):401–407. doi: 10.1016/j.freeradbiomed.2010.04.033

Figure 2.

Figure 2

Decreased PCR-amplifiable full length (16 kb) cardiac mtDNA in mice given repetitive injections of iron dextran for 4 weeks. Total DNA was isolated and amplified by QPCR as described under Materials and Methods. A: Full length mtDNA product was significantly decreased in hearts from iron treated mice while no changes were observed in the short (0.3 kb) PCR product (a control for input of mtDNA). B: No change in the amounts of either a long (13 kb) segment of the beta-globin gene or short (223 bp) segment after iron loading. *p<0.01 (Student's t test, two-tailed; n = 3 in each case).