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Decreased respiration of mitochondria from hearts of mice given repetitive injections of iron dextran for 4 weeks. A: Maximal oxygen consumption rates in the presence of the uncoupler CCCP were significantly decreased following iron loading. B: Similar iron-mediated decrements in respiration were also observed in the absence of an uncoupler; p<0.01 untreated vs. iron treated mice in both cases (Student's t test, two-tailed; n = 3 separate mitochondrial preparations in each case.
