Table 2.
Body and organ weights in control mice and mice given repetitive injections of iron dextran for a total of 4 weeks. Iron overload caused modest cardiac hypertrophy and increased hepatic weight. P < 0.01 compared to controls (n = 10 in each group).
| Treatment Group |
Initial Body Weight (g) |
Body Weight at Sacrifice (g) |
Heart Weight (g) |
Heart Weight/ Body Weight |
Liver Weight (g) |
Kidney Weight (g) |
|---|---|---|---|---|---|---|
| Saline Treatment |
26.21 ± 1.52 | 27.74 ± 2.03 | 0.134 ± 0.02 | 0.0049 ± 0.001 | 1.15 ± 0.11 | 0.43 ± 0.05 |
| Iron Treatment |
26.14 ± 0.83 | 23.46 ± 2.20 | 0.144 ± 0.02 | 0.0062 ± 0.001* | 2.30 ± 0.22* | 0.36 ± 0.05 |
*
p < 0.01 for saline treated mice vs. iron treated mice (Student’s t test, two-tailed).