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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2010 May 5;49(3):401–407. doi: 10.1016/j.freeradbiomed.2010.04.033

Table 4.

Decreased mRNA for respiratory chain components encoded by mtDNA but not those encoded by nuclear DNA in mice given repetitive injections of iron dextran for 4 weeks. Real-time rtPCR was used to detect levels of mRNA expression of mitochondrial genes (12S rRNA, COXI, ND4, and ND1) and nuclear genes (SDH, COXVb, NRF1, and GAPDH).

mRNA % OF CONTROL MtDNA
ENCODED		 nDNA
ENCODED
16S rRNA 41 ± 0.74* +
COXI 31 ± 0.93* +
ND4 30 ± 0.65* +
ND1 34 ± 1.41* +
SDH subunit b 141 ± 0.99 +
COXVb 112 ± 1.28 +
NRF1 116 ± 1.10 +
GAPDH 106 ± 1.00 +
*

p< 0.001 control (n = 3 in each case).