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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Neurosci Biobehav Rev. 2010 Feb 11;34(8):1223–1233. doi: 10.1016/j.neubiorev.2010.02.002

Figure 1. Adrenalectomy, but not demedullation, prevents the stress-induced enhancement of hippocampal dependent trace eyeblink conditioning (Beylin and Shors, 2003).

Figure 1

Stress increased the percentage of CRs emitted in sham operated but not in adrenalectomized (ADX) male rats (A). Note that basal levels of corticosterone were provided in drinking water. Demedullation (Demed), which leaves the adrenal cortex and corticosterone production intact, while removing adrenal catecholamine production, failed to prevent the stress-induced enhancement of trace conditioning, indicating that these effects are specific to corticosterone (B). Data are represented as Mean ± SEM percentage of CRs averaged across 300 training trials. Asterisks indicate a significant difference (p<0.05).