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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Exp Mol Pathol. 2010 Apr 28;89(1):1–8. doi: 10.1016/j.yexmp.2010.04.001

Fig 5.

Fig 5

The IIL UbD promoter was repressed by p53 protein. IFNg, but not TNFa, was able to induce the activity of the UbD promoter (D1 promoter) when the p53 consensus sequences were absent. However, IFNg is not able to induce the activity of D2 and D3 shorter UbD promoter, indicating the presence of an ISRE sequence in the IIL UbD promoter. (TNFa treatment: D1 vs. IIL p<0.001; IFNg treatment: D1 vs. IIL p=0.151; D1 vs. D1+IFNg p=0.005; TNFa+IFNg treatment: D1 vs. IIL p<0.001; D1 vs. D1+IFNg+TNFa p<0.001)