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. Author manuscript; available in PMC: 2011 Aug 11.
Published in final edited form as: Neuroscience. 2010 Apr 29;169(1):516–531. doi: 10.1016/j.neuroscience.2010.04.037

Figure 11. Immunization with Aβ does not improve outcomes in Asw/mTau−/− mice.

Figure 11

A. Immunization with Aβ reduces both the neuritic and non-neuritic plaque load in Asw mice (p=0. 014 and p=0. 035 respectively) only the non-neuritic but not neuritic plaque load in Asw/mTau−/− mice is decreased (p=0. 0244 and p=0. 6048 respectively). B. The number of spheroids remains unchanged in Asw/mTau−/− mice after Aβ immunization (p=0. 1658). C. Aβ immunization of Asw mice improves their ability to learn the radial arm water maze (ANOVA, p=0. 0051) while it decreases D. the ability of the Asw/mTau−/− mice to perform on the radial arm water maze (ANOVA, p=0. 0337). E. Quantitative results of soluble (s) and insoluble (i) Aβ 40 and 42 in whole brains of Asw and Asw/mTau−/− mice. * p<0. 05, ** p<0. 01, *** p<0. 001.