Table 1.
Diagnostic criteria for AIH
Parameters | Diagnosis of autoimmune hepatitis |
---|---|
Clinical | Female gender Associated with other autoimmune diseases |
Autoantibodies | ANA or SMA >1:40 (type 1) |
LKM >1:40 (type 2) | |
SLA+ (type 3) | |
Immunoglobulin | IgG > upper normal limit |
Biochemistry | Hepatitic picture (raised AST/ALT levels) |
Histology | Plasma cell-rich mononuclear infiltrate |
Interface hepatitis with ballooning and rosetting of periportal hepatocyte; +/− periportal fibrosis | |
Lobular necroinflammatory activity | |
No bile duct loss or chronic cholestasis | |
Radiology and ERCP | Normal |
Exclusion of other etiology | Exclude viral hepatitis, metabolic, drug, and alcoholic etiology |
Response to steroid | Good |