Fig. 4.
Disruption of TGF-β signaling by overexpression of antagonistic Smad7 suppresses the tumor progression induced by M-HTs in vivo. Tumor tissues were collected 18 days after cotransplantation. Immunohistochemistry employing standard histology (H&E, upper part) as well as anti-Smad2/3 (middle part) and anti-β-catenin (lower part) antibodies. Insets represent staining of tumor sections at higher magnification. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]