Figure 3.

NMR structure of the ErbB2 TMD in detergent (PDB-ID: 2jwa). (A) Side view of two ErbB2 TMD helices with highlighted GxxxG-like motifs and top view with highlighted orientation of the interaction motifs. (B) Ribbon and space filling representation of the two interacting helices with highlighted interaction motifs and the position of Val664 is indicated as well. (C) Helical-wheel representation of the ErbB2 TMD. Colors change every four residues for clarity. The SxxxG and the GxxxG motifs are highlighted. The angle between the two interaction motifs corresponds to approximately 120°.