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. 2010 Jun 14;107(26):11906–11911. doi: 10.1073/pnas.1002569107

Fig. 4.

Fig. 4.

IL-2–mediated pulmonary edema depends on CD25+ nonimmune cells. (A) WT mice received 5 daily injections of PBS or 200,000 IU IL-2 along with depleting mAbs to Thy1.2, NK1.1, CD25, or CD122. Pulmonary wet weight was determined on day 6. (B) Immune-depleted animals were generated as in Fig. 3D and received daily injections of PBS, 200,000 IU IL-2, or IL-2 plus anti-CD25 mAb. Pulmonary wet weight was determined on day 5. (C) CD25−/− mice or WT littermates received PBS or IL-2 as in A, followed by determination of pulmonary wet weight on day 6. (D) Mixed BM chimeras were generated with indicated combinations of WT or CD25−/− (KO) donor BM transferred to lethally irradiated WT or CD25−/− (KO) hosts and left for 6 wk, before treatment for 5 d with PBS or 200,000 IU IL-2. Pulmonary wet weight was calculated on day 6 by subtracting weights of PBS-treated from IL-2–treated animals. Data are representative of three independent experiments. ***P < 0.001; **P < 0.01; n.s., not significant.

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