Fig. 6.

Expression of COX-2 and DP1 receptor in biopsies from healthy subjects without (Ctrl) or with a prior history (Hx) of UC, UC patients with active disease, or UC patients in remission induced by 5-aminosalicylic acid (Sal) or immunomodulators/biologics (Imm). Cytoplasmic COX-2 expression (Top two panels) was present in the apical and crypt epithelial cells and up-regulated in patients with active disease. Immunostaining for DP1 receptor (arrows) showed expression in the connective tissue of lamina propria and in crypt epithelial cells, depicted in the longitudinal and transverse sections, respectively (Bottom two panels). Reduced DP1 expression was observed in patients with active disease. Images are representative of each treatment group and were taken at 100× for longitudinal biopsy sections stained for COX-2 and DP1 and 200× and 400× for transverse biopsy sections stained for COX-2 and DP1, respectively. (Magnification bar: 100 μm.)