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. 2010 Jun 14;107(26):11847–11852. doi: 10.1073/pnas.1007158107

Fig. 2.

Fig. 2.

Mov10l1−/− mice have a reduced testis size secondary to a lack of spermatids. (A) Scheme of the predicted MOV10L1 domains. For generation of Mov10l1−/− mice, the exon encoding the putative helicase domain (red) was flanked by LoxP sites, and global deletion of Mov10l1 was then achieved by breeding Mov10l1+/fl mice to CAG-Cre transgenic mice. (B) Mov10l1−/− mice showed reduced testis size compared with Mov10l1+/− and Mov10l1+/+ mice. (Left) Testes of 3-mo-old mice from the same litter. (Right) Testis weight of Mov10l1+/− and Mov10l1−/− mice. Each time point represents the mean of two to six testes. (C) Representative hematoxylin and eosin staining of transverse sections through testes of 3-mo-old wild-type versus Mov10l1−/− mice. (Lower) An enlargement of the regions indicated by the black frame in the Upper. ES, elongating spermatids; RS, round spermatids; PS, pachytene spermatocytes; DS, degenerating spermatocytes with condensed nuclei.