Table 1.

Comparison of experimental and simulated on/off (-600 mV vs. 0 mV) nicotine fluxes and their ratios

Study	Nicotine flux (μmoles/hr.cm2)	On (-600 mV)	Off (0 mV)	On/off ratio
Experiment 1	Observed	2.0	0.56	3.5
Experiment 2	Observed	1.2	0.29	4.3
Experiment 3	Observed	0.71	0.13	5.5
Average	Observed	1.3 ± 0.65	0.33 ± 0.22	4.4 ± 1.0
Experiment 1	Simulated	1.6	0.48	3.4
Experiment 2	Simulated	1.3	0.28	4.6
Experiment 3	Simulated	0.72	0.16	4.5
Average	Simulated	1.2 ± 0.49	0.31 ± 0.16	4.2 ± 0.67
Required flux	Calculated (see text)	1.1	0.30	3.6

The donor concentration used is 713 mM (116 mg/mL) pH8 nicotine aqueous solution, and the ionic strength is 0.35 M. Values reflect steady-state fluxes.