Table 1.

Demographic, clinical, volumetric and metabolic data for patients (1-21, sorted by disease duration) and controls (22-36).

Subject number	Age/gender	aDisease duration	EDSS	bLesion volume	cTf	NAA mM	Cr mM	Cho mM	mI mM
1	38/M	0.3	1	3.7	0.95	10.3	7.4	1.7	4.0
2	39/M	0.3	0	1.6	0.92	8.4	7.0	1.7	4.0
3	26/F	0.9	3.5	10.7	0.97	8.7	7.3	1.7	3.8
4	27/F	0.9	1	5.1	0.92	9.2	7.4	1.6	3.4
5	35/F	1.5	1.5	2.4	0.89	9.3	8.1	1.9	4.2
6	38/F	1.5	0	1.7	0.95	7.7	6.5	1.6	3.5
7	30/M	1.6	0	8.3	0.93	8.8	7.2	1.9	3.4
8	35/F	1.6	1	2.7	0.94	10.9	7.0	2.2	4.0
9	37/F	1.9	0	11.4	0.88	8.4	7.6	1.9	4.6
10	34/M	2.0	2	2.6	0.89	11.8	8.5	1.9	5.5
11	26/F	2.1	*4.0	1.6	0.84	11.8	8.2	2.4	3.1
12	42/F	2.1	0	4.2	0.98	9.0	7.5	1.9	3.6
13	21/F	2.3	1.5	23.2	0.94	9.0	8.3	2.0	5.5
14	28/M	2.3	1	5.7	0.97	8.5	7.3	1.9	4.4
15	32/F	2.7	2	7.3	0.90	8.8	7.9	1.8	4.8
16	29/M	3.2	1	4.9	0.88	11.3	8.5	2.1	3.7
17	29/F	3.4	2.5	16.5	0.85	8.8	6.8	1.7	4.0
18	27/F	4.0	2	11.2	0.94	11.3	9.0	2.1	4.2
19	42/F	4.5	1	1.2	0.90	9.9	8.2	1.8	4.3
20	38/F	4.9	2	2.2	0.94	11.1	8.7	2.0	3.9
21	31/F	5.2	2	2.8	0.94	8.9	7.1	1.6	3.7
22	20/F	-	-	-	0.93	9.5	6.8	1.8	3.5
23	25/F	-	-	-	0.97	11.1	7.8	2.0	2.2
24	26/F	-	-	-	0.93	9.7	7.0	1.7	3.9
25	26/F	-	-	-	0.90	11.3	8.2	1.8	4.2
26	27/M	-	-	-	0.96	9.0	6.5	1.6	3.3
27	28/M	-	-	-	0.94	7.9	5.7	1.4	3.1
28	28/F	-	-	-	0.94	10.3	8.2	1.7	3.2
29	28/F	-	-	-	0.87	9.0	7.9	1.7	3.9
30	29/F	-	-	-	0.95	7.9	6.5	1.2	3.1
31	29/F	-	-	-	0.94	9.8	6.9	1.8	3.1
32	31/F	-	-	-	0.91	8.7	6.2	1.4	3.1
33	35/M	-	-	-	0.94	8.3	6.6	1.5	3.8
34	36/F	-	-	-	0.95	11.8	8.1	1.7	4.0
35	37/F	-	-	-	0.99	8.8	6.7	1.6	3.8
36	44/F	-	-	-	0.92	10.4	7.2	1.8	3.0
Ctrl. avg.	30	-	-	-	0.94±0.03	9.6±1.2	7.1±0.8	1.6±0.2	3.4±0.5
Pat. avg.	33	2.3	1.38	6.2	0.92±0.04	9.6±1.3	7.7±0.7 d	1.9±0.2 d	4.1±0.6 d

^aYears

^binside the VOI, in cm³

^ctissue fraction

^dp<0.01.

The horizontal line separates patients (above) from controls (below).

^*EDSS dominated by permanent visual impairment in one eye.