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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: Eur Neuropsychopharmacol. 2008 Nov 6;19(4):238–249. doi: 10.1016/j.euroneuro.2008.09.004

Figure 1.

Figure 1

Panel A: mean (SEM) responses made on the active lever at each test of responding for the activation of an audiovisual compound stimulus before (i.e., Baseline; B) and after (Tests 1-5 Primes I & II) Pavlovian conditioning of this stimulus with IV infusions of cocaine (1 mg/kg/infusion). On Prime I session, all rats were injected with vehicle (V). On Prime II session, some rats (CVC, CMC and VVC) were injected with a 20 mg/kg cocaine prime (C). The * indicates a significant difference between VVV and CVC groups. The # indicates a significant difference between VVV and CVV groups. Panel B: mean (SEM) horizontal distance (cm) travelled by drug-naïve rats (VVV group) and cocaine conditioned/primed groups implanted with 30 mg/kg/day methadone-(CMC group) and vehicle-(CVC) filled mini-pumps. This test of locomotion activity was administered before the period of conditioning.