. Author manuscript; available in PMC: 2010 Jul 9.

Published in final edited form as: Eur Neuropsychopharmacol. 2008 Nov 6;19(4):238–249. doi: 10.1016/j.euroneuro.2008.09.004

Table 1.

Groups, sample size, experimental phase and corresponding drug treatment. Darkened rows highlight groups important for the behavioral assessment of steady-state methadone (SSM) exposure.

Groups	Sample Size	Test of baseline responding for a novel audiovisual stimulus 1 session (3h)	Pavlovian conditioning 1 (2h) and 2 (4h) sessions	Implantation of osmotic mini-pumps and subsequent tests of responding for the cocaine conditioned stimulus 5 sessions (3h)	Reinstatement tests (2 3h sessions) of responding for the cocaine conditioned stimulus following:
Groups	Sample Size		Pavlovian conditioning 1 (2h) and 2 (4h) sessions		Prime I	Prime II
VVV	8	No injections/drugs	Vehicle	Vehicle	Vehicle	Vehicle
VMV	8		Vehicle	Methadone	Vehicle	Vehicle
CMC	8		Cocaine	Methadone	Vehicle	Cocaine
CVC	10		Cocaine	Vehicle	Vehicle	Cocaine
CVV	7		Cocaine	Vehicle	Vehicle	Vehicle
VVC	8		Vehicle	Vehicle	Vehicle	Cocaine