Table 2.
Stereoselectivity in pinacol cyclization of 6 under modified conditions: 6 eq SmI2, THF, −78 °C; sat. aq. NaHCO3, −78 °C; warm to 20 °C.
| Compound | R | Ratio 7 : 8 |
|---|---|---|
| 6a | TIPS | >20:1 |
| 6c | TBS | 2.9:1 |
| 6d | TES | 2.7:1 |
| 6g | PMB | 1:1 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.