Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SPR analysis. Sensorgrams of the interaction of recombinant wild-type SHP2 or mutants at codons 42, 139, 279 and 468 with the biotinylated PTPNS1 BTAM peptide. Following binding of the phosphopeptide over a streptavidin-coated sensor chip, recombinant proteins were applied, and the amount of interacting protein was monitored by the change in arbitrary response units as a function of time at 25°C.
