Table 1.

Number of interacting phosphopeptides, and specific and shared binders of SHP2's wild-type N-SH2 and C-SH2 domains and related NS-causing mutants

Interacting peptides	N-SH2		C-SH2
	Wild-type	T42A	Wild-type	E139D
Total number of bindersa	73	156	78	90
Specific bindersb	6	89	31	43
Shared peptidesc
Wild-type N-SH2	—	67 (0.72)	24 (0.27)	50 (0.62)
Wild-type C-SH2	24 (0.27)	24 (0.33)	—	47 (0.76)

^aInteracting peptides were defined as binders with a signal higher than the average signal plus 1 standard deviation.

^bSpecific binders are phosphopeptides that were found to interact exclusively with individual SH2 domains.

^cNumber of recognized peptides shared by SH2 domains. The numbers in brackets refer to the Pearson's correlation coefficient resulting from binding experiments performed with the same phosphopeptide array challenged with the two indicated domains. Each experiment was performed in duplicate and showed a correlation coefficient higher than 0.9.