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. Author manuscript; available in PMC: 2010 Jul 9.
Published in final edited form as: Neuropsychopharmacology. 2008 Nov 19;34(6):1494–1503. doi: 10.1038/npp.2008.205

Figure 3.

Figure 3

Potentiated startle induced by footshock in CRF1 and CRF2 null mutation mice. Effects of ascending footshock intensity on startle reactivity were assessed in CRF1 and CRF2 receptor wild-type and knockout mice (WT and KO). Startle reactivity was tested immediately before (preshock baseline) the initial shock block and immediately after each block of footshocks (footshocks were presented in ascending order, 0.2, 0.4, and 0.8 mA, five per block). Half of the animals in each genotype received shock (Shock group) and the other half did not receive shock (No-Shock group). Data are represented as mean ± SEM of % change from initial preshock baseline reactivity to 90 dB startle pulse. N = 7–19, *p<0.05, **p<0.01 vs respective No Shock control, #p<0.05 vs. WT Shock, Tukey’s post hoc test.