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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Cell. 2010 Jun 24;141(7):1241–1252. doi: 10.1016/j.cell.2010.05.005

Figure 3. Structure of BT1754-PD in complex with fructose.

Figure 3

A. Representation of the homodimer of BT1754-PD present in the asymmetric unit, with each monomer separated by a dotted line; molecule of fructose (pink); the flexible hinge between the two subdomains (circle).

B. Overlay of BT1754-PD (green) with TtRBP (blue); the extended C-terminal helix in BT1754-PD (bracket) is unique to BT1754.

C. Side view of the binding site illustrating hydrophobic interactions of BT1754-PD and fructose. Fo-Fc electron density prior to modeling the single molecule of fructose in the β-furanose form is shown (blue mesh contoured at 3σ).

D. Top view of the binding site of BT1754-PD illustrating the numerous H-bonds (dotted black lines) with fructose.