Figure 2. Caveolin-1 deficiency results in elevated bacterial burdens.
A. Bacterial counts in the lungs or spleens of cav1 KO (Cav-1) and WT mice. Groups of mice (n=7) were infected IN with 1 × 108 cfu/mouse of P. aeruginosa strain PAO1. Animals were sacrificed at 6 h and 12 h after the infection, lungs were extracted, homogenized and the bacterial burden was established by plating different dilutions of the homogenate on cetrimide plates. The data are representative of two individual experiments. B. Groups of mice (n=7) were infected with 1 × 107 cfu/mouse of P. aeruginosa strain PAK IN. The data are representative of two individual experiments.