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Cross resistance patterns for Pt (II) spermine and Pd (II) spermine in A2780/CP cisplatin resistant cells. Comparison of cytotoxicity in A2780 vs. A2780/CP cells for (A) cisplatin, (B) Pd-spermine and (C) Pt-spermine complexes. Data presented are an average of 2-3 separate experiments, each experiment consisting of 5 replicates of each agent tested.
