Table II.
Comparison of changes in gene expression (increase or decrease relative to untreated control)a in A2780 cells following treatment with Pt (II) spermine, Pd (II) spermine and Cispt, DENSPM or Cispt/DENSPM under the same treatment conditions
| Gene | CisPt | DENSPM | CisPt/DEN | Pt (II)-spermine | Pd (II)-spermine |
|---|---|---|---|---|---|
| SSAT | 33 | 3 | 49 | NC | NC |
| SMO | 6 | 3 | 5.9 | 0.18 | 0.13 |
| SAMDC | 0.6 | NC | 0.5 | NC | NC |
| ARG2 | 2.3 | NC | 2.4 | 0.33 | 0.38 |
| NRF2 | 1.75 | NC | 2.1 | 0.42 | 0.46 |
| FAS | 16 | NC | 17 | 1.7 | NC |
| BAX | 4.5 | NC | 3.5 | 1.7 | 1.5 |
| BCL2 | 0.43 | NC | 0.37 | 0.5 | 0.5 |
| BIRC5 (Survivin) | 0.3 | NC | 0.4 | NC | NC |
| P21 | 93 | NC | 51 | 5 | 2.7 |
| MDM2 | 26 | NC | 29.7 | NC | NC |
| PCNA | 3.3 | NC | 2.8 | 1.5 | 1.6 |
| ERCC1 | 4 | NC | 2.6 | 0.6 | 0.6 |
| GGT1 | NC | NC | NC | 0.23 | 0.25 |
| OCT,1 | 3 | NC | 2.3 | NC | NC |
| OGG1 | NC | NC | 0.6 | 0.65 | 0.62 |
| PPARG | NC | NC | 0.5 | 0.6 | NC |
| PTGS2 (Cox2) | 1.8 | 0.7 | NC | 0.45 | 0.4 |
a
Values are RQ (relative expression, treated/control); rounded off. NC, no change. RQ value >1 denotes up-regulation and the value itself describes the fold increase in expression; RQ value <1 denotes down-regulation and the value itself is expression as a fraction of control.