Figure 1.

Stimulation of renin by inhibition of angiotensin II formation or action is Gsα-dependent. (A) PRC before (open bars) and 60 minutes after an intraperitoneal injection of 30 mg/kg body weight captopril (shaded bars) in wild-type mice (RC/GG, left) and in mice with JG cell-specific deletion of Gsα (RC/FF, right). (B) PRC before and after 50 mg quinaprilate in the same strains of mice. (C) PRC before and after 50 mg candesartan in the same strains of mice. Significances are given for comparisons with PRC before stimulation (paired t test).