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. 2010 Jun;21(6):955–965. doi: 10.1681/ASN.2009060662

Figure 7.

Figure 7.

S1P1Rs are necessary for PTEC survival during kidney IRI. (A) Plasma creatinine levels of PEPCK-Cre, PEPCK-CreS1P1fl/wt, and PEPCK-CreS1P1fl/fl mice pretreated with vehicle or SEW2871 1 hour before mild kidney ischemia (26 minutes) and 24 hours of reperfusion. †††P < 0.001 versus respective sham; ***P < 0.001, *P < 0.05 versus respective vehicle; ### P < 0.001 versus vehicle-treated PEPCK-Cre mice. (B through J) Representative H&E staining of mouse kidney sections after sham surgery or IRI (treatments as in A) from PEPCK-Cre sham (B), PEPCK-Cre vehicle (C), PEPCK-Cre SEW2871 (D), PEPCK-CreS1P1fl/wt sham (E), PEPCK-CreS1P1fl/wt vehicle (F) PEPCK-CreS1P1fl/wt SEW2871, (G), PEPCK-CreS1P1fl/fl sham (H), PEPCK-CreS1P1fl/fl vehicle (I), and PEPCK-CreS1P1fl/fl SEW2871 mice (J). (K) Semiquantitative tubular injury score of kidneys from sham-, vehicle-, and SEW2871-treated PEPCK-Cre, PEPCK-CreS1P1fl/wt, and PEPCK-CreS1P1fl/fl mice. Data are means ± SEM; n = 3 to 7. †††P < 0.001 versus respective sham; ***P < 0.001; ###P < 0.001 versus vehicle-treated control mice.