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. 2010 Jul 5;207(7):1555–1567. doi: 10.1084/jem.20100603

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© 2010 Gras et al.

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Figure 6. — Interactions with the polymorphic TCR residue. (a–c) Interaction between the TK3^WT (a), TK3^Gln55His (b), and TK3^Gln55Ala (c) TCRs with the peptide, localized at the polymorphic site of the β chain. The different chains are colored as in Fig. 4, the residues involved in the interaction are represented as sticks, and all of the panels show the same orientation of the different structures. (b) Loss of a direct H bond between the Arg66β and D7, and also between the Arg115α and the Ser112α in the TK3^Gln55His structure when compared with the TK3^WT (a). The loss of contacts is greater in the TK3^Gln55Ala structure (c) when compared with the TK3^WT complex (a). The blue and red dashed lines represent the vdw and polar interactions, respectively, and the red sphere represents a water molecule.